Signalling Pathways

Utilizing a network of interacting proteins, intracellular signalling pathways transmit various extracellular signals into the cell to regulate gene expression and induce different cell responses. With optogenetic design to optically control the interaction and function of signalling proteins,  the corresponding intracellular signalling pathway can be activated by light.

TrKa scheme
Optogenetic control of TrkA signalling

Nerve growth factor/tropomyosin receptor kinase A (NGF/TrkA) signaling plays a key role in neuronal development, function, survival, and growth. Based on the light-modulated protein-protein interactions,  the optical control over TrkA sginalling is developed.

ACS Synth. Biol., 2018, 7 (7), 1685. <LINK>

AKTph translocated to the cell membrane upon the light-induced activation of TrkA signalling
ERK translocated to the cell nucleus upon the light-induced activation of TrkA signalling